Giannis Antetokounmpo and Khris Middleton combined for 49 points as the Bucks outscored the Pacers 61-44 in the second half of a 19-point victory on Wednesday night at Fiserv Forum.
The win comes after the Bucks lost to the Heat on Monday, and moved the Bucks back to a 9.5 game lead in the Eastern Conference standings on the Toronto Raptors.
Indiana, a possible first-round opponent for Milwaukee, made a charge in the second quarter, bringing the score to within two points at the break. Steady defense and a hot night at the free throw line (20 for 22, or 90.9%) helped Milwaukee earn the win.
Former Bucks guard Malcolm Brogdon scored just four points in 11 minutes.
Next up for Milwaukee is the start of a three-game West Coast road trip: a highly-anticipated showdown between the Bucks and Lakers Friday night in Los Angeles.
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Video: NBA